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KMID : 0370219810250040145
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Yakhak Hoeji
1981 Volume.25 No. 4 p.145 ~ p.151
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The Effect of Ginseng on Hepatic Drug Metabolizing Enzyme in Rats
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이태하/Lee TH
김낙두/Kim ND
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Abstract
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The effect of ginseng methanol extract on hepatic drug metabolizing enzyme in rat was investigated. The ginseng methanol extract (100mg/kg) was administered orally to Sprague Dawley rats for 7 days and the contents of cytochrome P450 and NADPH cytochrome c reductase in liver were measured bv the method of Stanton et al. and Mazel respectively. The content of liver cytochrome P450 and NADPH cytochrome c reductase in the rats treated with ginseng methanol extract (100mg/kg) were increased by 21.9% and 16.6% respectively and their increases were statistically significant. Single i.p. injection of phenobarbital (100mg/kg) to the rats produced approximately 25% increase in cytochrome P450 content in this investigation and further stimulation was produced in the rats pretreated with ginseng methanol extract (100mg/kg). On the other hand, single i.p. injection of 95% CCl4 (0.5ml/kg) showed 29% decrease in cytochrome P450 content and 10.5% decrease in NADPH cytochrome c reductase activity. The degree of inhibition of cytochrome P450 content in the rats pretreated with ginseng methanol extract (100mg/kg) was similar to that observed in the CCl4 alone treated group, but NADPH cytochrome c reductase activity was increased by 65% in the rats pretreated with ginseng methanol extract (100mg/kg). These results suggest that ginseng is the hepatic drug metabolizing enzyme inducing agent in the rat and the effect is similar to phenobarbital.
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